Structure of PDB 6uz8 Chain A

Receptor sequence
>6uz8A (length=734) Species: 9606 (Homo sapiens) [Search protein sequence]
AYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQ
NALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHP
AFAEGKRLATQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKG
ARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSED
PVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEV
EAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWY
ENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMK
FVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFS
WMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFI
ARFMAFWHASKAQSIIDKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAI
AVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIG
MFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIE
NIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWF
SYFEEGRTLPVPFNLVRQYQKIMKRLIKRYTTQAQIDKESDEVNEGELKE
IKQDISSLRYELLEEKSQNTEDLAELIRELGEKL
3D structure
PDB6uz8 Structural basis for pharmacological modulation of the TRPC6 channel.
ChainA
Resolution2.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SBM A A611 Y612 Q624 L627 G628 V631 A510 Y511 Q523 L526 G527 V530
BS02 Y01 A Y392 M403 K406 I613 Y300 M311 K314 I512
BS03 Y01 A K698 F699 I703 K597 F598 I602
BS04 R0D A E672 F675 F679 E571 F574 F578
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0042803 protein homodimerization activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007338 single fertilization
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex
GO:0036057 slit diaphragm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6uz8, PDBe:6uz8, PDBj:6uz8
PDBsum6uz8
PubMed32149605
UniProtQ9Y210|TRPC6_HUMAN Short transient receptor potential channel 6 (Gene Name=TRPC6)

[Back to BioLiP]