Structure of PDB 6uyc Chain A

Receptor sequence
>6uycA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHGAPPLESVD
VRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGGFYGVSSQYES
LEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVN
FLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSER
GAQHHIYRLVR
3D structure
PDB6uyc Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.
ChainA
Resolution1.658 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QLV A F233 V329 L383 L387 I408 Q410 Y426 F428 F17 V94 L148 L152 I173 Q175 Y191 F193 MOAD: Kd=229nM
External links
PDB RCSB:6uyc, PDBe:6uyc, PDBj:6uyc
PDBsum6uyc
PubMed32579935
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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