Structure of PDB 6uy4 Chain A

Receptor sequence
>6uy4A (length=354) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SGNEHFYKDWFLPTARLLVRDGETAHNLSVYLASYGFIPHKQRNSFPQLK
CKVFGLEFDHPIGLAAGFDKDGKAFMGLLNAGFSHIEVGTVTPNPQLGNA
RPRIFRWTEKEAVVNRCGFNSDGHDAVYERLKDRPWEGRGVIGVNLGCNK
TSADPTADYVAGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLRDLLSK
VLAARNQLSKKTPILLKISPDENDQNLKDIVEVALDSKTRIDGMIISNTT
LTTYEEAVACGAAPIPGNNKQNVVYGGLSGRPLFEKSTDCLRKVSALTKG
AIPLIGVGGISCGEDALSKLNAGASLVQLYTSFVYQGPPVAHKVAREINK
LKMT
3D structure
PDB6uy4 Structural basis for the function and inhibition of dihydroorotate dehydrogenase from Schistosoma mansoni.
ChainA
Resolution2.796 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N139 F143 S203 N205 T206 K241 N272
Catalytic site (residue number reindexed from 1) N115 F119 S179 N181 T182 K217 N248
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QLA A A49 H50 S53 I128 R130 F357 V358 A25 H26 S29 I104 R106 F333 V334 BindingDB: IC50=1000nM
BS02 FMN A A90 G91 T114 N139 N200 K241 N272 S303 G304 G332 G333 Y354 T355 A66 G67 T90 N115 N176 K217 N248 S279 G280 G308 G309 Y330 T331
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uy4, PDBe:6uy4, PDBj:6uy4
PDBsum6uy4
PubMed32428996
UniProtG4VFD7

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