Structure of PDB 6uwx Chain A

Receptor sequence
>6uwxA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6uwx Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.
ChainA
Resolution1.307 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QKD A W81 P82 F83 L94 Y139 N140 I146 W40 P41 F42 L53 Y98 N99 I105 MOAD: Kd=290uM
BindingDB: Kd=290000nM
External links
PDB RCSB:6uwx, PDBe:6uwx, PDBj:6uwx
PDBsum6uwx
PubMed31857841
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]