Structure of PDB 6uwu Chain A

Receptor sequence
>6uwuA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6uwu Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QKP A P82 F83 V87 L92 L94 N140 I146 P40 F41 V45 L50 L52 N98 I104 MOAD: ic50~70nM
BindingDB: Kd=718nM,IC50=280nM
External links
PDB RCSB:6uwu, PDBe:6uwu, PDBj:6uwu
PDBsum6uwu
PubMed32255647
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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