Structure of PDB 6uux Chain A

Receptor sequence
>6uuxA (length=257) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
GAMIESSTTIQVISAGLPRTGTKSLKNALEIIYHKPCYHMFEIIFNKQSD
IIKWQNLIHDSHMITTPLTTKTIAIYDKLKELLDGYIATTDLPTCGFYKD
LMNIYPNAKVLLTIRDKYDWLHSLRKVVLPKSNDPWKLKIEEGDKVLGLN
SDFYKLTEDSLKFAFQKDDLNFDDDQVLLECYDEYNRLVQETVPSDRLLV
LRLGDGWEPLCKFLNVEIPNGIDYPCVNSHHQMTQLTEQLIKYKSLDAII
HMFPDLI
3D structure
PDB6uux Molecular basis for hycanthone drug action in schistosome parasites.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P A R17 T18 G19 T20 K21 S22 R115 S123 L203 X226 N228 S229 H230 R19 T20 G21 T22 K23 S24 R115 S123 L203 X226 N228 S229 H230
BS02 QHM A M38 D91 L92 V128 D144 F153 T157 T237 M40 D91 L92 V128 D144 F153 T157 T237 MOAD: Kd=22uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:6uux, PDBe:6uux, PDBj:6uux
PDBsum6uux
PubMed32027942
UniProtG4VLE5

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