Structure of PDB 6uuq Chain A

Receptor sequence
>6uuqA (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
SHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQE
KNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYF
SIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVY
DACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYG
PMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLL
SILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYE
NNVMNIRQFNC
3D structure
PDB6uuq The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin.
ChainA
Resolution1.849 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L275 Y288 M290 F299 Y324 N327 V328 M329 N330 I331 Q333 F334 C336 L250 Y263 M265 F274 Y299 N302 V303 M304 N305 I306 Q308 F309 C311
BS02 ZN A D90 H92 D118 D65 H67 D93
BS03 FE A D118 N150 H199 H281 D93 N125 H174 H256
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:6uuq, PDBe:6uuq, PDBj:6uuq
PDBsum6uuq
PubMed32936779
UniProtQ08209|PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (Gene Name=PPP3CA)

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