Structure of PDB 6uuo Chain A

Receptor sequence
>6uuoA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
WEIPDGQITVGQRIFGTVYKGKWHGDVAVKMLNVTPTPQQLQAFKNEVGV
LRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLI
DIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFFEQLSGSIL
WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEM
VGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELA
RELS
3D structure
PDB6uuo Functional characterization of a PROTAC directed against BRAF mutant V600E.
ChainA
Resolution3.288 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D122 K124 N126 N127 D140 S148
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QH1 A A481 W531 C532 F583 D594 F595 A28 W77 C78 F129 D140 F141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6uuo, PDBe:6uuo, PDBj:6uuo
PDBsum6uuo
PubMed32778845
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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