Structure of PDB 6usr Chain A

Receptor sequence

>6usrA (length=592) Species: 7070 (Tribolium castaneum)

MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKNFRLCKKHKTKKPVQILA
LLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSFECIHLSVLHKCYDYDAI
PWLQNVEPNLRPKLLLKHNLFLLDNIVKPIIAFYYKPIKTLNGHEIKFIR
KEEYISFESKVFHKLKKMKYLVEVQDEVKPRGVLNIIPKQDNFRAIVSIF
PDSARKPFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKTQGQIYGIKV
DIRDAYGNVKIPVLCKLIQSIPTHLLDSEKKNFIVDHISNQFVAFRRKIY
KWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKDAFIHRTVDDYFFCSP
HPHKVYDFELLIKGVYQVNPTKTRTNLPTHRHPQDEIPYCGKIFNLTTRQ
VRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTK
FEFNTVFNDQRTVFANFYDAMICVAYKFDAAMMALRTSFLVNDFGFIWLV
LSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEI
YKGLIDRIKSKLTMHDGEVDASYFCKLPEKFRFVKINRKASI

3D structure

• PDB: 6usr Mechanisms of nucleotide selection by telomerase.
• Chain: A
• Resolution: 2.93 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	D343 G391 F417 K418 N423 P442 F443 N446 K477	D343 G391 F417 K418 N423 P442 F443 N446 K477
BS02	rna	A	V197 S198 Y217 G309 D310 F441 P442 C445 R511	V197 S198 Y217 G309 D310 F441 P442 C445 R511
BS03	MG	A	D251 I252 D343	D251 I252 D343
BS04	MG	A	D251 D344	D251 D344
BS05	G2P	A	K189 R194 R253 D254 Y256 Q308 G309 D343	K189 R194 R253 D254 Y256 Q308 G309 D343

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:6usr, PDBe:6usr, PDBj:6usr
• PDBsum: 6usr
• PubMed: 32501800
• UniProt: Q0QHL8