Structure of PDB 6usc Chain A

Receptor sequence
>6uscA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
PSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVAS
VHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDY
KNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLF
GIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAG
FVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFS
GFDWSGYGTHVGYSSSREITEAAVLLFYR
3D structure
PDB6usc Stereoelectronic Effects Impact Glycan Recognition.
ChainA
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N260 E262 E274 N226 E228 E240
BS02 CA A H86 G97 D133 D282 H52 G63 D99 D248
BS03 CA A E87 D89 G92 D98 E53 D55 G58 D64
BS04 KO2 A N260 H263 E274 W288 Y297 N226 H229 E240 W254 Y263 MOAD: ic50=0.7mM
BS05 KO2 A T173 P208 T139 P174 MOAD: ic50=0.7mM
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0009624 response to nematode
GO:0046326 positive regulation of D-glucose import
GO:0070207 protein homotrimerization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031526 brush border membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0070062 extracellular exosome
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usc, PDBe:6usc, PDBj:6usc
PDBsum6usc
PubMed31930911
UniProtQ8WWA0|ITLN1_HUMAN Intelectin-1 (Gene Name=ITLN1)

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