Structure of PDB 6urx Chain A

Receptor sequence
>6urxA (length=259) Species: 3988 (Ricinus communis) [Search protein sequence]
KQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPI
NQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEA
ITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYY
YSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPS
VITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIA
LMVYRCAPP
3D structure
PDB6urx Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V81 E177 R180
Catalytic site (residue number reindexed from 1) V78 E174 R177
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JMG A Y183 R234 R235 F240 Y180 R231 R232 F237 MOAD: ic50=181uM
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:6urx, PDBe:6urx, PDBj:6urx
PDBsum6urx
PubMed32428396
UniProtP02879|RICI_RICCO Ricin

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