Structure of PDB 6urq Chain A

Receptor sequence
>6urqA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRV
RIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMD
LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRE
RLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS
LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA
KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGN
EAVQQILSE
3D structure
PDB6urq Tissue-Specific Regulation of the Wnt/ beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R368 S370 L375 G378 Y379 N408 Y412 H414 D432 W434 F436 E441 R447 R36 S38 L43 G46 Y47 N76 Y80 H82 D100 W102 F104 E109 R115
External links
PDB RCSB:6urq, PDBe:6urq, PDBj:6urq
PDBsum6urq
PubMed32698014
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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