Structure of PDB 6uqe Chain A

Receptor sequence
>6uqeA (length=562) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGV
GKTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFK
ALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRV
IGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAH
HDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRK
KTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIE
ALTEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLR
FDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEK
AHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGSTDAMEEIKK
IFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQ
EARNWLAEKGYDRAMGARPMARVIQDNLKKPLANELLFGSLVDGGQVTVA
LDKEKNELTYGF
3D structure
PDB6uqe Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y259 R260 G298 Y91 R92 G130
BS02 peptide A Y540 V541 Y372 V373
BS03 ADP A L188 I189 G217 G219 K220 T221 A222 I357 D396 L20 I21 G49 G51 K52 T53 A54 I189 D228
BS04 ADP A F461 G498 V499 G500 K501 T502 E503 F665 A701 R702 F293 G330 V331 G332 K333 T334 E335 F481 A517 R518
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6uqe, PDBe:6uqe, PDBj:6uqe
PDBsum6uqe
PubMed32313240
UniProtP0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

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