Structure of PDB 6uox Chain A

Receptor sequence
>6uoxA (length=1161) Species: 9606 (Homo sapiens) [Search protein sequence]
SCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSL
CCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNV
TATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKAL
GLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNA
TKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMW
ITYMAFLLVFFGAFCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLV
FVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHI
YQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICL
APLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRA
PASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNN
YYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDS
DVFTVVISYAIMFLYISLALGHVDSKVSLGIAGILIVLSSVACSLGVFSY
IGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRV
LGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQIT
CFVSLLGLDIKRQEKNRLDESCLFRFFKNSYSPLLLKDWMRPIVIAIFVG
VLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLE
EGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWID
DYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGD
FMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTV
LQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTI
IDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWL
WGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHM
GSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFL
PVLLSYIGPSV
3D structure
PDB6uox Structural basis for itraconazole-mediated NPC1 inhibition.
ChainA
Resolution4.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QDG A V378 W381 V624 L684 I685 I687 Q862 F1087 I1220 V309 W312 V555 L607 I608 I610 Q768 F993 I1126
Gene Ontology
Molecular Function
GO:0005319 lipid transporter activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6uox, PDBe:6uox, PDBj:6uox
PDBsum6uox
PubMed31919352
UniProtO15118|NPC1_HUMAN NPC intracellular cholesterol transporter 1 (Gene Name=NPC1)

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