Structure of PDB 6uo9 Chain A

Receptor sequence
>6uo9A (length=675) Species: 9606 (Homo sapiens) [Search protein sequence]
RRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHH
DSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLS
YGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTT
EVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLF
YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMT
EAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQE
APLAYDAIWALALALNKTSRLEDFNYNNQTITDQIYRAMNSSSFEGVSGH
VVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPP
ADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQN
SQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGF
SLGYGSMFTKIWWVHTVFTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLH
RTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGI
FLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFA
FASLAIVFSSYITLVVLFVPKMRRL
3D structure
PDB6uo9 Structural basis of the activation of a metabotropic GABA receptor.
ChainA
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QD7 A W182 S247 G268 S270 W395 W16 S81 G102 S104 W229 BindingDB: EC50=200nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004965 G protein-coupled GABA receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uo9, PDBe:6uo9, PDBj:6uo9
PDBsum6uo9
PubMed32555460
UniProtQ9UBS5|GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (Gene Name=GABBR1)

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