Structure of PDB 6unq Chain A

Receptor sequence
>6unqA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
RQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV
MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSC
LRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCIADLGL
AVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAF
GLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNI
PNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKATLT
3D structure
PDB6unq Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G217 R218 V222 A233 K235 Y285 H286 K338 L343 G12 R13 V17 A28 K30 Y80 H81 K131 L136
BS02 MG A N341 D354 N134 D147
BS03 MG A F237 E248 D354 F32 E43 D147
BS04 MG A E248 Y252 A353 D354 E43 Y47 A146 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6unq, PDBe:6unq, PDBj:6unq
PDBsum6unq
PubMed34400635
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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