Structure of PDB 6unp Chain A

Receptor sequence

>6unpA (length=302) Species: 9606 (Homo sapiens)

DLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYR
VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDW
VSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV
ISDFGLSMRLTGNRLVRPEVGTIRYMAPEVLEGAVNLRDCESALKQVDMY
ALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREK
QRPKFPEAWKENSLAVRSLKETIEDCWGQDAEARLTAQCAEERMAELMMI
WE

3D structure

• PDB: 6unp Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.30: receptor protein serine/threonine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	I209 G212 Y214 G215 V217 A228 K230 M279 Y282 R337 L340 D351	I11 G14 Y16 G17 V19 A30 K32 M81 Y84 R139 L142 D153
BS02	ADP	A	G360 N361 R362	G162 N163 R164
BS03	MG	A	N338 D351	N140 D153
BS04	MG	A	W298 C302	W100 C104
BS05	MG	A	R381 M383 Y407	R174 M176 Y200
BS06	MG	A	A235 N236 R237 Q238	A37 N38 R39 Q40
BS07	MG	A	G212 R213	G14 R15

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004675 transmembrane receptor protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6unp, PDBe:6unp, PDBj:6unp
• PDBsum: 6unp
• PubMed: 34400635
• UniProt: Q13873|BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (Gene Name=BMPR2)