Structure of PDB 6uky Chain A

Receptor sequence
>6ukyA (length=172) Species: 9606,559292 [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHAVSQRLYILLPLDCGVPD
NLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQRAGTCVLE
YATPLQTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADASQNNCRLI
AYQEPSSFSLSQEVLRHLRQEE
3D structure
PDB6uky An orally available non-nucleotide STING agonist with antitumor activity.
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QBD A S162 Y163 Y167 R238 T263 S9 Y10 Y14 R78 T103 MOAD: ic50=10nM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031386 protein tag activity
GO:0042802 identical protein binding
GO:0044389 ubiquitin-like protein ligase binding
Biological Process
GO:0002218 activation of innate immune response
GO:0016925 protein sumoylation
GO:0032481 positive regulation of type I interferon production
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005940 septin ring

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6uky, PDBe:6uky, PDBj:6uky
PDBsum6uky
PubMed32820094
UniProtQ12306|SMT3_YEAST Ubiquitin-like protein SMT3 (Gene Name=SMT3);
Q86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

[Back to BioLiP]