Structure of PDB 6uj1 Chain A

Receptor sequence
>6uj1A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
LAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYID
TYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNI
ATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV
FSMQMCGAGLPGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKL
EIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASFSDG
FWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPML
NYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGA
AVSEISGPFSTASNCVP
3D structure
PDB6uj1 A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors.
ChainA
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.45: memapsin 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L3M A D48 G50 K86 Y87 T88 Q89 F124 Y211 D241 G243 T244 T245 L246 R248 D33 G35 K71 Y72 T73 Q74 F109 Y192 D222 G224 T225 T226 L227 R229
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uj1, PDBe:6uj1, PDBj:6uj1
PDBsum6uj1
PubMed33544569
UniProtQ9Y5Z0|BACE2_HUMAN Beta-secretase 2 (Gene Name=BACE2)

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