Structure of PDB 6uez Chain A

Receptor sequence
>6uezA (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
KGKLPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFT
YLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQK
KMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTA
SHCLHGKEIRSQLNEKVAQLYADLAGGFSHAAWLLPGWLPLPSFRRRDRA
HREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLI
GLLLAGQATSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQ
LKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPT
VNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAY
VQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRS
3D structure
PDB6uez A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.154: sterol 14alpha-demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A Y131 Y145 F152 A311 T315 P376 I377 M380 R382 P441 F442 H447 C449 I450 G451 A455 Y75 Y89 F96 A255 T259 P320 I321 M324 R326 P385 F386 H391 C393 I394 G395 A399
BS02 LAN A Y131 F139 Y145 F234 G307 I377 I379 Y75 F83 Y89 F178 G251 I321 I323
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:6uez, PDBe:6uez, PDBj:6uez
PDBsum6uez
PubMed32493730
UniProtQ16850|CP51A_HUMAN Lanosterol 14-alpha demethylase (Gene Name=CYP51A1)

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