Structure of PDB 6ue6 Chain A

Receptor sequence
>6ue6A (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
KDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKKSARQYHVQF
FGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISG
KLRAQWEMGIVQAEEAASMSVEERKAKFTFLY
3D structure
PDB6ue6 Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q5D A Y233 W236 F266 G268 A270 E272 Q321 Y20 W23 F50 G52 A54 E56 Q105
BS02 Q5D A K317 A320 K101 A104
External links
PDB RCSB:6ue6, PDBe:6ue6, PDBj:6ue6
PDBsum6ue6
PubMed33522809
UniProtO96028|NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (Gene Name=NSD2)

[Back to BioLiP]