Structure of PDB 6udu Chain A

Receptor sequence
>6uduA (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
VEDLEG
3D structure
PDB6udu Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q4Y A H224 A227 V249 M250 V253 R263 T266 L267 F270 I294 H54 A57 V79 M80 V83 R93 T96 L97 F100 I124 MOAD: ic50=1.7nM
PDBbind-CN: -logKd/Ki=9.30,Ki=0.5nM
BindingDB: IC50=1.7nM,Ki=0.500000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6udu, PDBe:6udu, PDBj:6udu
PDBsum6udu
PubMed31736296
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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