Structure of PDB 6uab Chain A

Receptor sequence
>6uabA (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
SDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
VEDLE
3D structure
PDB6uab Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H224 V249 H252 V253 N260 G262 R263 T266 F318 F319 E322 H54 V79 H82 V83 N90 G92 R93 T96 F148 F149 E152
BS02 ADM A M231 V253 M61 V83
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6uab, PDBe:6uab, PDBj:6uab
PDBsum6uab
PubMed
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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