Structure of PDB 6u8z Chain A

Receptor sequence
>6u8zA (length=568) Species: 9606 (Homo sapiens) [Search protein sequence]
KDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSP
EIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTK
RTLMRLHPNIKVMRHPDHVLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDN
EHRLTDVGSVFWHGKDYCNFVFKDWVIDRYSTPRMPWHDIASAVHGKAAR
DVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTELRYQVPGSVHANVQ
LLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVV
FNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGGGNALQAIMHFNYR
TMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSK
LLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQA
GRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIY
DKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFP
FYFLSEESLLPVPMEVWT
3D structure
PDB6u8z Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2and RhoA.
ChainA
Resolution1.799 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.4: phospholipase D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO3 A H464 K466 H896 K898 H124 K126 H398 K400
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6u8z, PDBe:6u8z, PDBj:6u8z
PDBsum6u8z
PubMed32198492
UniProtQ13393|PLD1_HUMAN Phospholipase D1 (Gene Name=PLD1)

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