Structure of PDB 6u8w Chain A

Receptor sequence
>6u8wA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTASNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB6u8w Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
ChainA
Resolution2.94892 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P659 K782 R823 P97 K220 R261
BS02 dna A S649 C651 S655 V657 E697 V699 R733 Q772 T773 T776 G784 G831 R832 S87 C89 S93 V95 E135 V137 R171 Q210 T211 T214 G222 G269 R270
BS03 SAH A F581 D582 G583 T586 S604 E605 V606 D627 V628 G648 R832 S833 W834 F19 D20 G21 T24 S42 E43 V44 D65 V66 G86 R270 S271 W272 BindingDB: IC50=300nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6u8w, PDBe:6u8w, PDBj:6u8w
PDBsum6u8w
PubMed32620778
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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