Structure of PDB 6u8p Chain A

Receptor sequence

>6u8pA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]

LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFP
VHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE

3D structure

PDB

6u8p Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

Chain

Resolution

3.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	V657 P659 G824	V95 P97 G262
BS02	dna	A	S649 C651 N652 S655 V657 E697 V699 R733 Q772 T773 T776 G784 G831 R832	S87 C89 N90 S93 V95 E135 V137 R171 Q210 T211 T214 G222 G269 R270
BS03	SAH	A	F581 D582 G583 I584 T586 E605 V606 D627 V628 G648 P650 R832 S833 W834	F19 D20 G21 I22 T24 E43 V44 D65 V66 G86 P88 R270 S271 W272	BindingDB: IC50=300nM

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:6u8p, PDBe:6u8p, PDBj:6u8p
PDBsum	6u8p
PubMed	32620778
UniProt	Q9UBC3\|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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