Structure of PDB 6u7l Chain A

Receptor sequence
>6u7lA (length=460) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
TPTAFYIKVHDTDNVAIIVNDNGLKAGTRFPDGLELIEHIPQGHKVALLD
IPANGEIIRYGEVIGYAVRAIPRGSWIDESMVVLPEAPPLHTLPLATKVP
EPLPPLEGYTFEGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERD
LLPKYPNVDGVVGLNHLYGCGAPAAVVPIRTIHNISLNPNFGGEVMVIGK
HVGFQSMVEDILQIAERHLQKLNQRQRETCPASELVVGMQCGGSDAFSGV
TANPAVGYASDLLVRCGATVMFSEVTEVRDAIHLLTPRAVNEEVGKRLLE
EMEWYDNYLNGGLANVVEKALGSIAKSGKSAIVEVLSPGQRPTKRGLIYA
ATPASDFVCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANR
WFDLMDINAGTIATGEETIEEVGWKLFHFILDVASGKKKTFSDQWGLHNQ
LAVFNPAPVT
3D structure
PDB6u7l Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.42: galactarate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A Q287 C288 E321 A417 D419 Q240 C241 E274 A354 D356
Gene Ontology
Molecular Function
GO:0008198 ferrous iron binding
GO:0008867 galactarate dehydratase activity
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0019698 D-galacturonate catabolic process
GO:0046392 galactarate catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6u7l, PDBe:6u7l, PDBj:6u7l
PDBsum6u7l
PubMed31811683
UniProtP39829|GARD_ECOLI Galactarate dehydratase (L-threo-forming) (Gene Name=garD)

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