Structure of PDB 6u67 Chain A

Receptor sequence
>6u67A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB6u67 Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q01 A L246 S247 M250 F254 R263 T266 L267 F270 I294 L75 S76 M79 F83 R92 T95 L96 F99 I123 MOAD: Ki=0.95uM
BindingDB: Ki=950nM
BS02 Q01 A H224 G262 T266 F319 H53 G91 T95 F148 MOAD: Ki=0.95uM
BindingDB: Ki=950nM
BS03 BNL A R263 T266 R92 T95
BS04 Q01 A M231 L235 M60 L64 MOAD: Ki=0.95uM
BindingDB: Ki=950nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6u67, PDBe:6u67, PDBj:6u67
PDBsum6u67
PubMed31971799
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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