Structure of PDB 6u5l Chain A

Receptor sequence
>6u5lA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
SGMENFILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVR
LTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVV
REFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGE
NLEEFFALVAAEEASMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLL
YEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDG
LLQRDPQKRLTWTRLLQHSFWKKAFA
3D structure
PDB6u5l High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D121 S123 K126 N139 S174 S182
Catalytic site (residue number reindexed from 1) D123 S125 K128 N141 S165 S173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3RJ A I10 R12 V18 A31 L33 W46 V75 C78 G81 L128 I12 R14 V20 A33 L35 W48 V77 C80 G83 L130
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6u5l, PDBe:6u5l, PDBj:6u5l
PDBsum6u5l
PubMed31841327
UniProtQ96C45|ULK4_HUMAN Serine/threonine-protein kinase ULK4 (Gene Name=ULK4)

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