Structure of PDB 6u1i Chain A

Receptor sequence
>6u1iA (length=300) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MRVLLIAGGVSPEHEVSLLSAEGVLRHIPFPTDLAVIAQDGRWLLGEKAL
TALEAKAAPEGEHPFPPPLSWERYDVVFPLLHGRFGEDGTVQGFLELLGK
PYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKPVVPFDPPFFVK
PANTGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVF
GEASPVGEVRAELLIPAPLDPGTQETVQELALKAYKVLGVRGMARVDFFL
AEGELYLNELNTIPGFTTSMYPRLFEAGGVAYPELLRRLVELALTHHHHH
3D structure
PDB6u1i d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V16 L19 H82 R268 G288 T292
Catalytic site (residue number reindexed from 1) V16 L19 H82 R245 G265 T268
Enzyme Commision number 6.3.2.4: D-alanine--D-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A F151 K153 G158 A191 L192 E197 F272 N281 E282 F148 K150 G155 A184 L185 E190 F249 N258 E259
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6u1i, PDBe:6u1i, PDBj:6u1i
PDBsum6u1i
PubMed32335509
UniProtQ5SHZ3|DDL_THET8 D-alanine--D-alanine ligase (Gene Name=ddl)

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