Structure of PDB 6u10 Chain A

Receptor sequence
>6u10A (length=269) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence]
AEAPLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAV
LLDGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRT
GAHVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGI
AFTAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYP
RLIEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYA
DAAEKKFDAQLARETAGTR
3D structure
PDB6u10 Crystal Structure of the metallo-beta-lactamase L1 from Stenotrophomonas maltophilia in the complex with the inhibitor captopril.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H105 H107 D109 H110 H181 Y212 H246
Catalytic site (residue number reindexed from 1) H84 H86 D88 H89 H160 Y191 H225
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D109 H110 H246 D88 H89 H225
BS02 ZN A H105 H107 H181 H84 H86 H160
BS03 X8Z A Y32 D109 I149 H181 P210 Y11 D88 I128 H160 P189
BS04 X8Z A A136 R137 A115 R116
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6u10, PDBe:6u10, PDBj:6u10
PDBsum6u10
PubMed
UniProtB2FTM1

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