Structure of PDB 6tzx Chain A

Receptor sequence
>6tzxA (length=223) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
STTTKYIFVPIATIGCGKTTVFNTLNNLFPQWTHIQNNNISKKAKLKICD
LTLLALEDDDQSVVLFDRNNSASRERRQIFTTIDQKRDEHLDDTVDLKYI
AINFIPEDLSEEELWDITYNRVIQRGDNHQSIKSQLDENLVESVMKGFIQ
RYQPINTSRSPDDQFDHVIHLKLSKDENSLKSSLENVRIIIDDLVQNFPD
LIKEKPADELINECFQKALDYKP
3D structure
PDB6tzx Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
ChainA
Resolution1.529 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.3: RNA ligase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IDP A G422 G424 K425 T426 T427 R528 R532 G533 D534 D583 K588 S590 L626 G15 G17 K18 T19 T20 R121 R125 G126 D127 D176 K181 S183 L219
BS02 PO4 A K425 N445 H536 K18 N38 H129
Gene Ontology
Molecular Function
GO:0003972 RNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation

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Molecular Function
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Biological Process
External links
PDB RCSB:6tzx, PDBe:6tzx, PDBj:6tzx
PDBsum6tzx
PubMed31722405
UniProtP43075|TRNL_CANAL tRNA ligase (Gene Name=LIG1)

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