Structure of PDB 6tz8 Chain A

Receptor sequence
>6tz8A (length=372) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
GENLYFQEIVSTTERVIKDVQAPAMYVPTDDQFWSKVDKTKPDIAFLKNH
FYREGRLTEEQALYILEKGGELLRSEPNLLEVDAPITVCGDIHGQYYDLM
KLFEVGGNPADTRYLFLGDYVDRGYFSIECVLYLWSLKMWYPDTLFLLRG
NHECRHLTDYFTFKLECKHKYSETVYNACMESFCNLPLAAVMNKQFLCIH
GGLSPELHTLDDLRSINRFREPPTQGLMCDILWADPLEDFGSEKTNENFL
HNHVRGCSYFFTYNAACQFLERNNLLSIIRAHEAQDAGYRMYRKTKTTGF
PSVMTIFSAPNYLDVYSNKAAVLKYESNVMNIRQFNCTPHPYWLPNFMDV
FTWSLPFVGEKITDMLIAILNC
3D structure
PDB6tz8 Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D120 H122 D148 H311 D91 H93 D119 H282
BS02 ZN A D148 N180 H229 H311 D119 N151 H200 H282
BS03 FK5 A W382 F386 E389 W353 F357 E360
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:6tz8, PDBe:6tz8, PDBj:6tz8
PDBsum6tz8
PubMed31537789
UniProtO42773|PP2B1_CRYNH Serine/threonine-protein phosphatase 2B catalytic subunit A1 (Gene Name=CNA1)

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