Structure of PDB 6tz7 Chain A

Receptor sequence
>6tz7A (length=358) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
TLERVIKEVQAPALSTPTDEMFWSPEDPSKPNLQFLKQHFYREGRLTEEQ
ALWIIHAGTQILRSEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPSE
TRYLFLGDYVDRGYFSIECVLYLWALKIWYPNSLWLLRGNHECRHLTDYF
TFKLECKHKYSERIYEACIESFCALPLAAVMNKQFLCIHGGLSPELHTLE
DIKSIDRFREPPTHGLMCDILWADPLEEFGQEKTGDYFVHNSVRGCSYFF
SYPAACAFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPN
YLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEK
ITDMLIAI
3D structure
PDB6tz7 Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D116 N148 H197 H279 D108 N140 H189 H271
BS02 FE A D88 H90 D116 D80 H82 D108
BS03 FK5 A W350 P353 F354 E357 W342 P345 F346 E349
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:6tz7, PDBe:6tz7, PDBj:6tz7
PDBsum6tz7
PubMed31537789
UniProtQ4WUR1|PP2B_ASPFU Serine/threonine-protein phosphatase 2B catalytic subunit (Gene Name=cnaA)

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