Structure of PDB 6tz2 Chain A

Receptor sequence

>6tz2A (length=1208) Species: 110829 (Bombyx mori cypovirus 1)

TELYNTIFSETRKFTRESFKEIEHLTAKLANDRVARHDFLFNNSIALISD
YSGEDSNGNQLQATVTIPNEITNPKEYDPSDYPLAEDESFFKQGHKYDYL
VTFRAGSLTNTYEPKTKMYKLHAALDKLMHVKQRKSRFADLWRELCAVIA
SLDVWYQTTNYPLRTYVKLLFHKGDEFPFYESPSQDKIIFNDKSVASILP
TFVYTCCQVGTAIMSGILTHVESIVAMNHFLHCAKDSYIDEKLKIKGIGR
SWYQEALHNVGRATVPVWSQFNEVIGHRTKTTSEPHFVSSTFISLRAKRA
ELLYPEFNEYINRALRLSKTQNDVANYYAACRAMTNDGTFLATLTELSLD
AAVFPRIEQRLVTRPAVLMSNTRHESLKQKYANGVGSIAQSYLSSFTDEI
AKRVNGIHHDEAWLNFLTTSSPGRKLTEIEKLEVGGDVAAWSNSRIVMQA
VFAREYRTPERIFKSLKAPIKLVERQQSDRRQRAISGLDNDRLFLSFMPY
TIGKQIYDLNDNAAQGKQAGNAFDIGEMLYWTSQRNVLLSSIDVAGMDAS
VTTNTKDIYNTFVLDVASKCTVPRFGPYYAKNMEVFEVGKRQSQVKYVNA
AWQACALEAANSQTSTSYESEIFGQVKNAEGTYPSGRADTSTHHTVLLQG
LVRGNELKRASDGKNSCLTTIKILGDDIMEIFQGNENDTHDHAVSNASIL
NESGFATTAELSQNSIVLLQQLVVNGTFWGFADRISLWTREDTKDIGRLN
LAMMELNALIDDLLFRVRRPEGLKMLGFFCGAICLRRFTLSVDNKLYDST
YNNLSKYMTLVKYDKNPDFDSTLMSLILPLAWLFMPRGGEYPAYPFERRD
GTFTEDESMFTARGAYKRRLLYDVSNIREMIQQNSMVLDDDLLHEYGFTG
ALLLIDLNILDLIDEVKKEDISPVKVNELATSLEQLGKLGEREKSRRAAS
DLKIRGHALSNDIVYGYGLQEKIQKSAMATKETTVQSKRVSSRLHEVIVA
KTRDYKIPTMPADALHLYEFEVEDVTVDLLPHAKHTSYSNLAYNMSFGSD
GWFAFALLGGLDRSANLLRLDVASIRGNYHKFSYDDPVFKQGYKIYKSDA
TLLNDFFVAISAGPKEQGILLRAFAYYSLYGNVEYHYVLSPRQLFFLSDN
PVSAERLVRIPPSYYVSTQCRALYNIFSYLHILRSITSNQGKRLGMVLHP
GLIAYVRG

3D structure

• PDB: 6tz2 Conservative transcription in three steps visualized in a double-stranded RNA virus.
• Chain: A
• Resolution: 3.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	T422 R484 L678 D681 Q724 I739 E759 D766 K976 N1070 R1073 H1084 K1085	T418 R480 L674 D677 Q720 I735 E755 D762 K972 N1066 R1069 H1080 K1081
BS02	rna	A	S188 Q189 F823 S825 L827 K922 R993	S184 Q185 F819 S821 L823 K918 R989
BS03	rna	A	F420 T423 S425 P426 N447 V477 I489 Y504 Q519 Q522 R641 R841 V1142 P1145	F416 T419 S421 P422 N443 V473 I485 Y500 Q515 Q518 R637 R837 V1138 P1141
BS04	ATP	A	R37 D144 R147 Y184 N195 R791	R33 D140 R143 Y180 N191 R787
BS05	UTP	A	R485 R487 G550 D552 D680	R481 R483 G546 D548 D676
BS06	MG	A	D680 D681	D676 D677

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0019079 viral genome replication

External links

• PDB: RCSB:6tz2, PDBe:6tz2, PDBj:6tz2
• PDBsum: 6tz2
• PubMed: 31695188
• UniProt: Q993A4