Structure of PDB 6typ Chain A

Receptor sequence
>6typA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
RLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLY
AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHI
YAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV
GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY
DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGH
TFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
3D structure
PDB6typ Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PKG A Y334 G364 R415 F478 R483 S508 Y525 S555 A556 Y572 S602 G603 Y9 G39 R90 F153 R158 S183 Y200 S230 A231 Y247 S277 G278 MOAD: Kd=2.7nM
BindingDB: Kd=2.7nM
External links
PDB RCSB:6typ, PDBe:6typ, PDBj:6typ
PDBsum6typ
PubMed31898999
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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