Structure of PDB 6ty4 Chain A

Receptor sequence
>6ty4A (length=621) Species: 9031 (Gallus gallus) [Search protein sequence]
ERVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACY
GLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGF
LNQFTEDKPTLNFFYQQVKNDYMLEIADQVDQEIALKLGCLEIRRSYGEM
RGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFAN
LNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYL
TDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPS
LTIAENMADLIDGYCRLVNGATQSFIIRPDDYAEIIDEEDTYTMPSTRDY
EIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVR
EKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRK
FSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDF
GLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEI
LMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR
RPRFTELKAQLSTILEEEKLQ
3D structure
PDB6ty4 Structural basis of Focal Adhesion Kinase activation on lipid membranes.
ChainA
Resolution5.96 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D546 R550 N551 D564
Catalytic site (residue number reindexed from 1) D481 R485 N486 D499
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G429 G431 Q432 K454 L501 C502 E506 L553 D564 G364 G366 Q367 K389 L436 C437 E441 L488 D499
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005856 cytoskeleton

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ty4, PDBe:6ty4, PDBj:6ty4
PDBsum6ty4
PubMed32779739
UniProtQ00944|FAK1_CHICK Focal adhesion kinase 1 (Gene Name=PTK2)

[Back to BioLiP]