Structure of PDB 6txc Chain A

Receptor sequence

>6txcA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

VDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGAS
HNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHG
PFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIP
EEDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6txc Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.84 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FE	A	H167 H206 D207 D311	H56 H95 D96 D193
BS02	0KX	A	Q149 L150 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q38 L39 R53 D96 H104 H122 D193 K194 Y197 D201 R248 Y256
BS03	GTP	A	K116 V117 I118 D137 R145	K5 V6 I7 D26 R34
BS04	DTP	A	R333 R352 K354 N358 K523	R215 R234 K236 N240 K405
BS05	GTP	A	Y155 V156 V378 R451	Y44 V45 V260 R333
BS06	DTP	A	I118 N119	I7 N8
BS07	DTP	A	V156 F157 R372 H376 K377	V45 F46 R254 H258 K259

External links

PDB	RCSB:6txc, PDBe:6txc, PDBj:6txc
PDBsum	6txc
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]