Structure of PDB 6tx5 Chain A

Receptor sequence

>6tx5A (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]

GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKGE

3D structure

PDB

6tx5 Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51.

Chain

Resolution

1.08 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1)	Y45 F55 D56 I75 Y101 F118
Enzyme Commision number	5.2.1.8: peptidylprolyl isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	4MZ	A	D68 W90 Y113	D56 W78 Y101	MOAD: Kd=2.9nM BindingDB: Kd=2900000nM

Gene Ontology

	Molecular Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity

External links

PDB	RCSB:6tx5, PDBe:6tx5, PDBj:6tx5
PDBsum	6tx5
PubMed	32420743
UniProt	Q13451\|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)