Structure of PDB 6tx4 Chain A

Receptor sequence
>6tx4A (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKGE
3D structure
PDB6tx4 Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51.
ChainA
Resolution1.06 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1) Y45 F55 D56 I75 Y101 F118
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HRZ A Y57 V86 I87 W90 Y45 V74 I75 W78 MOAD: Kd=1.3nM
BS02 HRZ A T46 A95 T34 A83 MOAD: Kd=1.3nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:6tx4, PDBe:6tx4, PDBj:6tx4
PDBsum6tx4
PubMed32420743
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

[Back to BioLiP]