Structure of PDB 6tx0 Chain A

Receptor sequence

>6tx0A (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]

TMKVINDPIHGHIELHPLLVRIINTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF
SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE
DICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCH
HLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTK
LTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRE
DYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFY
CKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQ
WCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6tx0 Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.01 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FE	A	H167 H206 D207 D311	H54 H93 D94 D190
BS02	MG	A	D207 H233	D94 H120
BS03	DZ4	A	Q149 L150 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q36 L37 R51 D94 H102 H120 D190 K191 Y194 D198 R245 Y253
BS04	CZF	A	K116 V117 I118 N137 R145	K3 V4 I5 N24 R32
BS05	DZ4	A	V156 F157 R372 H376 K377	V43 F44 R251 H255 K256
BS06	DZ4	A	V117 N119	V4 N6
BS07	CZF	A	Y155 V156 V378 R451 K455	Y42 V43 V257 R330 K334

External links

PDB	RCSB:6tx0, PDBe:6tx0, PDBj:6tx0
PDBsum	6tx0
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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