Structure of PDB 6twt Chain A

Receptor sequence
>6twtA (length=224) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
TGDQRFGDLVFRQLAPNVWQHTSYLAVASNGLIVRDGGRVLVVDTAWTDD
QTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSN
QLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITV
GIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMI
VMSHSAPDSRAAITHTARMADKLR
3D structure
PDB6twt Flexible loops of New Delhi metallo-beta-lactamase modulate its activity towards different substrates.
ChainA
Resolution0.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H120 H122 D124 H189 C208 K211 N220 H250
Catalytic site (residue number reindexed from 1) H74 H76 D78 H143 C162 K165 N174 H204
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H120 H122 H189 H74 H76 H143
BS02 ZN A D124 C208 H250 D78 C162 H204
BS03 CA A E152 D223 E106 D177
BS04 CA A D95 D130 D49 D84
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6twt, PDBe:6twt, PDBj:6twt
PDBsum6twt
PubMed32353499
UniProtC7C422|BLAN1_KLEPN Metallo-beta-lactamase type 2 (Gene Name=blaNDM-1)

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