Structure of PDB 6twb Chain A

Receptor sequence
>6twbA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVGYGDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
3D structure
PDB6twb De novo development of proteolytically resistant therapeutic peptides for oral administration.
ChainA
Resolution2.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 S188
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N49 C122 L123 L239 Q243 N36 C113 L114 L232 Q236
BS02 peptide A H57 A97 E98 Y171 D189 C191 K192 S195 S214 W215 G216 E217 G218 H44 A88 E89 Y162 D182 C184 K185 S188 S207 W208 G209 E210 G211
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6twb, PDBe:6twb, PDBj:6twb
PDBsum6twb
PubMed32393891
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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