Structure of PDB 6tw4 Chain A

Receptor sequence
>6tw4A (length=226) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
ATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQL
PPEEGGLNGSAMYIDTENTFRPERLREIAQNRGLDPDEVLDNVAYARAFN
SNHQMLLVQQAEDMIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAER
QQKLAKHLADLHRLANLYDIAVFVTNQVGHILAHSATLRVYLRKGKGGKR
IARLIDAPHLPEGEAVFSITEKGIED
3D structure
PDB6tw4 A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NZW A M169 I171 F177 P179 A201 Y202 A203 M62 I64 F70 P72 A94 Y95 A96
BS02 CA A G141 G143 K144 T145 Q146 G34 G36 K37 T38 Q39
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6tw4, PDBe:6tw4, PDBj:6tw4
PDBsum6tw4
PubMed33662256
UniProtO74036|RADA_PYRFU DNA repair and recombination protein RadA (Gene Name=radA)

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