Structure of PDB 6tv4 Chain A

Receptor sequence
>6tv4A (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
DLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCD
SRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDV
WSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTG
VLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDTICAPTEAI
RRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDE
AQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEI
IIRSHWTDVQVKGTSLPRALHCWDRSLHDPLKGCPVHLVDSCPWPHCNPS
CPT
3D structure
PDB6tv4 Caffeine inhibits Notum activity by binding at the catalytic pocket.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CFF A W128 V187 F268 P287 F320 A342 V346 W41 V100 F181 P196 F229 A251 V255 MOAD: Kd=85uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6tv4, PDBe:6tv4, PDBj:6tv4
PDBsum6tv4
PubMed33033363
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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