Structure of PDB 6tuo Chain A

Receptor sequence

>6tuoA (length=405) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence]

GLTYRIGNGASVPISNTGELIKGLRNYGPYEVPSLKYNQIALIHNNQFSS
LINQLKSQISSKIDEVWHIHNINISEFIYDSPHFDSIKSQVDNAIDTGVD
GIMLVLPEYNTPLYYKLKSYLINSIPSQFMRYDILSNRNLTFYVDNLLVQ
FVSKLGGKPWILNVDPEKGSDIIIGTGATRIDNVNLFCFAMVFKKDGTML
WNEISPIVTSSEYLTYLKSTIKKVVYGFKKSNPDWDVEKLTLHVSGKRPK
MKDGETKILKETVEELKKQEMVSRDVKYAILHLNETHPFWVMHPYEGTKV
KLSSKRYLLTLLQPYLMVTPIKPLSVEIVSDNWTSEEYYHNVHEILDEIY
YLSKMNWRGFRSRNLPVTVNYPKLVAGIIANVNRYGGYPINPEGNRSLQT
NPWFL

3D structure

PDB

6tuo Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	N119 T120 Y123 K127 Q137 F138 M139 R140 R147 Y152 N155 Q159 K163 P330 Y331 L332 R380 L427	N110 T111 Y114 K118 Q128 F129 M130 R131 R138 Y143 N146 Q150 K154 P314 Y315 L316 R358 L405
BS02	dna	A	T26 G27 I30 R147 F151 D154 N155 R383	T17 G18 I21 R138 F142 D145 N146 R361
BS03	MG	A	Q159 L427	Q150 L405

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6tuo, PDBe:6tuo, PDBj:6tuo
PDBsum	6tuo
PubMed
UniProt	O28951\|PIWI_ARCFU Piwi protein (Gene Name=AF_1318)

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