Structure of PDB 6tug Chain A

Receptor sequence
>6tugA (length=408) Species: 888064 (Enterococcus italicus DSM 15952) [Search protein sequence]
NAMKILFSPIGNTDPWRNDRDGAMLHIVRHYQPDRVVLFFTESIWQGNQH
FSGQQAFDWVKIIQSINENCQIEIKCDTIEVENDFDAYKDLFHQYLVEEK
RKYPNAEIFLNVTSGTPQMETTLCLEYVTYPDKMRCIQVSTPLTKYAQAD
CQEVDLEIVNEEESQQPSRCHKIAILSFREAIVRNQIKSLLDNYDYEAAL
QLVASQKSFRNGKEIRKKLKELIDDIKMHRVFSYLIKQYPRNEKLQKALL
HTILLEMRHQRGDIAETLIRVKSIAEYIVEQYIQKNYPYLIIYKEDKPYF
NVSYSQELTESYLALMDSGFPAYRDFLQLLEASNEMTNEMNKVNEINNLR
NKVAHNLDSLNLDRDKNGRKITNAVTAVRTMLLAVFPEVQENDFHYLKQF
NQSIKELL
3D structure
PDB6tug Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AF2 A N10 T11 T111 T139 P140 N12 T13 T113 T141 P142
BS02 AF2 A E80 N81 T114 P115 E82 N83 T116 P117
BS03 AF2 A N10 T39 I42 G113 T114 N12 T41 I44 G115 T116
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6tug, PDBe:6tug, PDBj:6tug
PDBsum6tug
PubMed32221291
UniProtE6LHV2|CSM6_ENTI1 CRISPR system endoribonuclease Csm6 (Gene Name=csm6)

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