Structure of PDB 6tu9 Chain A

Receptor sequence
>6tu9A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
KPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLK
DYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGD
LHEFLIMRSDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLH
VKISDLGLSREIYSADYYRSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVL
WEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEI
PSRRPRFKDIHVRLRSW
3D structure
PDB6tu9 Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
ChainA
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D615 R619 N620 D633
Catalytic site (residue number reindexed from 1) D137 R141 N142 D155
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A A504 E523 M527 F552 Y554 I555 V612 H613 L622 S632 D633 A45 E64 M68 F93 Y95 I96 V134 H135 L144 S154 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6tu9, PDBe:6tu9, PDBj:6tu9
PDBsum6tu9
PubMed32619402
UniProtQ01973|ROR1_HUMAN Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Gene Name=ROR1)

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