Structure of PDB 6tse Chain A

Receptor sequence
>6tseA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVILESIFLKRSQQKKKTSPLNFKKCLFLLTVHKLSYYEYDFERGRRGS
KKGSIDVEKITCVETVVPEKNPPPERQIPRRGEMEQISIIERFPYPFQVV
YDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCC
SQTAKNAMGCQILE
3D structure
PDB6tse Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
ChainA
Resolution1.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 72V A K12 F30 L37 Y39 S55 I56 L111 K11 F29 L36 Y38 S54 I55 L106
BS02 72V A N24 K26 K53 N23 K25 K52
BS03 72V A K12 S14 K26 Y39 K11 S13 K25 Y38
BS04 ZN A H143 C154 C155 C165 H138 C149 C150 C160
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6tse, PDBe:6tse, PDBj:6tse
PDBsum6tse
PubMed
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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