Structure of PDB 6ts4 Chain A

Receptor sequence
>6ts4A (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYTDSQRPISLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDAGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
3D structure
PDB6ts4 Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
ChainA
Resolution1.17 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 A195
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 A188
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J7B A H57 D189 C191 K192 G193 A195 W215 G216 G218 H44 D182 C184 K185 G186 A188 W208 G209 G211 MOAD: ic50=2.8uM
BindingDB: IC50=2800nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ts4, PDBe:6ts4, PDBj:6ts4
PDBsum6ts4
PubMed32551603
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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